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So far Astrid has created 14 blog entries.

Study for the Development of a COVID-19 Disease Severity Test

IUVE Bio is currently working on a study for the development of a COVID-19 disease severity test IUVE Bio is currently working on a study for the development of a COVID-19 disease severity test The aim is to analyze the proteomic plasma profile of SARS-Cov-2 patients with the aid of a machine learning approach to derive a novel diagnostic test for the prediction of disease severity in patients suffering from SARS-Cov-2. The development of such a diagnostic test is of high potential impact as it will allow health care providers to stratify patients and plan for the availability and allocation of medical and infrastructural resources required for adequate clinical care. Currently, there is no test that can predict COVID-19 disease severity. The development of this diagnostic test will use a COVID-19 patient’s immune-profile and apply machine learning to predict COVID-19 disease severity and can also be used as a companion diagnostic tool. This test will allow doctors to prioritize high-risk patients and make informed decisions on treatment choice, use of scarce therapeutic resources, and predict whether a COVID-19 patient will need an ICU bed and ventilator. At a population scale, when used with antibody-based COVID-19 tests, our test will provide actionable information to local and federal governments and healthcare organizations to drive resource allocation and deployment. Furthermore, while the elderly population and subjects with pre-existing comorbidities (e.g. hypertension and T2D) are at greatest risk, severe cases have also been registered in the younger population with no clear explanation regarding their susceptibility. If you are interested in partnering with us for joint projects, please contact Asli Gozoren at Asli@iuvebio.com About IUVE Bio IUVE Bio is a spin-out company from the ‘Stanford 1,000 Immunomes Project’ which received $30M in funding from the NIH/NIHA during the course of the 10-year research. The project followed 1,000 people up to 10 years to discover the association between immune health and disease. The resulting ‘Inflammatory Age’ score is a measure of the degree of a weakened immunity, which can predict multiple chronic diseases, and in this current pandemic, reduce global disease [...]

2020-05-13T21:32:34-07:00May 13th, 2020|News|

White Paper: The critical role of understanding chronic inflammation

In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress.

2020-04-25T23:23:19-07:00April 25th, 2020|Publication by our Team Members|

Chronic inflammation in the etiology of disease across the life span

In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress.

2020-04-25T23:01:25-07:00April 25th, 2020|Publication by our Team Members|

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy

Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved.

2019-08-08T22:01:02-07:00February 7th, 2017|Publication by our Team Members|

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Low-grade chronic inflammation has been associated with many of the diseases associated with aging, but the mechanisms that produce this inflammation are poorly understood.

2019-08-08T21:42:29-07:00January 16th, 2017|Publication by our Team Members|

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

A longitudinal study reveals in older adults systemically reduced immune cell signaling responses that are stable at least 3 years and are predictive of cardiovascular disease.

2019-08-08T20:25:46-07:00October 26th, 2016|Publication by our Team Members|

Understanding Inflammation

Inflammation has been found to be an underlying cause in many diseases, making it a hot topic in the health media. But what do we really know about chronic inflammation and its effects on the body?

2019-08-08T19:08:44-07:00May 20th, 2016|Scientific Literature|

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

Inflammation has been found to be an underlying cause in many diseases, making it a hot topic in the health media. But what do we really know about chronic inflammation and its effects on the body?

2019-08-08T20:58:45-07:00July 29th, 2015|Scientific Literature|

Cytomegalovirus infection enhances the immune response to influenza

Cytomegalovirus (CMV) is a b-herpesvirus present in a latent form in most people worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious clinical complications, but the effect of the latent state on healthy people remains elusive.

2019-08-08T22:02:25-07:00April 1st, 2015|Publication by our Team Members|

Systemic Inflammation Predicts All-Cause Mortality: A Glasgow Inflammation Outcome Study

Markers of the systemic inflammatory response, including C-reactive protein and albumin, as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.

2019-08-08T20:40:40-07:00March 2nd, 2015|Scientific Literature|