We developed a deep-learning method based on patterns of systemic age-related inflammation. The resulting inflammatory clock of aging (iAge) tracked with multimorbidity, immunosenescence, frailty and cardiovascular aging, and is also associated with exceptional longevity in centenarians.
It is now a consensus in the scientific community that Systemic Chronic Inflammation (SCI), arising as an immune response to environmental and social insults, is the root cause of many diseases.
The importance of novel inflammatory biomarkers immune profiling in prediction of coronavirus disease severity.
In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress.
Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved.
Low-grade chronic inflammation has been associated with many of the diseases associated with aging, but the mechanisms that produce this inflammation are poorly understood.
A longitudinal study reveals in older adults systemically reduced immune cell signaling responses that are stable at least 3 years and are predictive of cardiovascular disease.
Cytomegalovirus (CMV) is a b-herpesvirus present in a latent form in most people worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious clinical complications, but the effect of the latent state on healthy people remains elusive.
There are marked differences between the sexes in their immune response to infections and vaccination, with females often having significantly higher responses.
